Study on the expression of C-erbB-2 gene in coal miners with pneumoconiosis complicated by pulmonary cancer / 中华劳动卫生职业病杂志
Chinese Journal of Industrial Hygiene and Occupational Diseases
;
(12): 169-171, 2003.
Article
Dans Chinois
| WPRIM
| ID: wpr-265089
ABSTRACT
<p><b>OBJECTIVE</b>To study the difference in the expressions of C-erbB-2 gene between the coal miners with pneumoconiosis complicated by pulmonary cancer and the controls with single pulmonary cancer, and its relation to clinical pathology.</p><p><b>METHOD</b>Measuring the expressions of C-erbB-2 in 32 cases of pneumoconiosis complicated by pulmonary cancer and those in 30 cases of pulmonary cancer by means of immunohistochemistry.</p><p><b>RESULTS</b>The positive expression rate in 32 cases of pneumoconiosis complicated by pulmonary cancer was 53.13% whereas that in 30 cases of single pulmonary cancer was 26.67% (P < 0.05); the positive expressions of C-erbB-2 in patients with lymph node metastasis (70.59% in pneumoconiosis group, 50.00% in controls) were significantly different from those without lymph node metastasis (33.33% in pneumoconiosis group, 11.11% in controls) (P < 0.05). The prognosis on patients with positive expressions of C-erbB-2 was poor, and was not related to pathologic category.</p><p><b>CONCLUSION</b>C-erbB-2 gene may be an important regulating gene in the coal miners with pneumoconiosis complicated by pulmonary cancer, and as a reference index to determine lymph node metastasis and prognosis.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Pneumoconiose
/
Pronostic
/
Expression des gènes
/
Analyse de survie
/
Chine
/
Industrie minière charbon
/
Récepteur ErbB-2
/
Gènes erbB-2
/
Génétique
Type d'étude:
Étude pronostique
Limites du sujet:
Adulte très âgé
/
Humains
/
Mâle
Pays comme sujet:
Asie
langue:
Chinois
Texte intégral:
Chinese Journal of Industrial Hygiene and Occupational Diseases
Année:
2003
Type:
Article
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