Effect of qianjin huanglian pill on kidney in insulin resistance mice / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 889-892, 2009.
Article
Dans Chinois
| WPRIM
| ID: wpr-265345
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of qianjin huanglian pill on kidney in monosodium L-glutamate (MSG)-treated insulin resistance (IR) mice.</p><p><b>METHOD</b>The ameliorative effect of qianjin huanglian pill on IR in MSG mice was evaluated in comparison with rosiglitazone (Ros). The fasting serum glucose, fasting serum insulin, insulin sensitivity index, urinary albumin excretion, glomerular diameter and pathological changes of kidney were investigated in the evaluation.</p><p><b>RESULT</b>After 2 weeks of qianjin huanglian pill treatment, the urinary albumin excretion (UAE) was reduced in low-dose group (P < 0.05) as compared with the model group. After 4 weeks of qianjin huanglian pill treatment, the fasting serum glucose was reduced in high-dose group (P < 0.001 compared with the model group). ISI of mice was ameliorated in high-dose group (P < 0.05 compared with the model group). The glomerular diameter was decreased, the hyperplasia of glomerulus was ameliorated in high-dose and low-dose groups (P < 0.01 compared with model group).</p><p><b>CONCLUSION</b>In MSG mice, we found qianjin huanglian pill could increase insulin sensitivity, decrease the urinary albumin excretion, ameliorate the pathological changes of kidney due to insulin resistance.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Pharmacologie
/
Glutamate de sodium
/
Glycémie
/
Insulinorésistance
/
Médicaments issus de plantes chinoises
/
Chimie pharmaceutique
/
Relation dose-effet des médicaments
/
Toxicité
/
Rein
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
China Journal of Chinese Materia Medica
Année:
2009
Type:
Article
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