Phospholipid scramblase 1 / 生理学报
Acta Physiologica Sinica
;
(6): 501-510, 2006.
Article
Dans Anglais
| WPRIM
| ID: wpr-265422
ABSTRACT
Phospholipid scramblase 1 (PLSCR1) is a calcium-binding, multiply palmitoylated type II endofacial plasma membrane protein, while unpalmitoylated PLSCR1 protein can import into the nucleus, where it binds to genomic DNA. Although the original work showed that PLSCR1 contributes to the transbilayer movement of phospholipids, the following studies revealed that PLSCR1 expression can be induced by some cytokines such as interferon, epidermal growth factor, and also by leukemic cell differentiation-inducing agents such as all-trans retinoic acid (ATRA) and phorbol 12-myristate 13-acetate (PMA). PLSCR1 was also shown to interact with several protein kinases including c-Abl, c-Src, protein kinase Cdelta as well as some other proteins such as onzin, suggesting the roles of PLSCR1 in cell signaling. Indeed, the current evidence proposes that PLSCR1 contributes to cell proliferation, differentiation, apoptosis, and plays roles in the pathogenesis of cancers, especially leukemia.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Phospholipides
/
Physiologie
/
Protein kinases
/
Leucémies
/
Différenciation cellulaire
/
Cytokines
/
Apoptose
/
Protéines de transfert des phospholipides
/
Prolifération cellulaire
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Acta Physiologica Sinica
Année:
2006
Type:
Article
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