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Oligomeric interaction between ryanodine receptors: potential role in Ca(2+) release / 生理学报
Acta Physiologica Sinica ; (6): 305-308, 2006.
Article Dans Anglais | WPRIM | ID: wpr-265451
ABSTRACT
Receptor proteins in both eukaryotic and prokaryotic cells often form regular lattice or array in the membrane. Recent theoretical analyses indicate that such arrays may provide a novel mechanism for receptor signaling regulation in cells. The functional coupling between neighboring receptors could improve the signaling performance. The ryanodine receptors (RyR)/calcium release channels usually form 2-D regular lattice in the endoplasmic/sarcoplasmic reticulum membranes. Thus, RyR is a potentially good model to study the function of receptor 2-D array. In this article, we briefly review recent progresses in this research field, including RyR-RyR interaction, RyR array's function and working mechanisms. The investigations performed by new methods in our laboratory are summarized. We demonstrate that the RyR-RyR interaction is modulated by the functional states of RyRs. Accordingly, the mechanism of "dynamic coupling" of RyR array is proposed. Its possible role in RyR-mediated Ca(2+) release is discussed.
Sujets)
Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Physiologie / Réticulum sarcoplasmique / Cations / Calcium / Muscles squelettiques / Canal de libération du calcium du récepteur à la ryanodine / Interactions entre récepteurs / Métabolisme Type d'étude: Étude pronostique Limites du sujet: Animaux / Humains langue: Anglais Texte intégral: Acta Physiologica Sinica Année: 2006 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Physiologie / Réticulum sarcoplasmique / Cations / Calcium / Muscles squelettiques / Canal de libération du calcium du récepteur à la ryanodine / Interactions entre récepteurs / Métabolisme Type d'étude: Étude pronostique Limites du sujet: Animaux / Humains langue: Anglais Texte intégral: Acta Physiologica Sinica Année: 2006 Type: Article