Studies on formulations of Panax notoginsenosides for intranasal administration / 药学学报

ABSTRACT

<p><b>AIM</b>To develop high bioavailability preparations without irritation for Panax notoginsenosides.</p><p><b>METHODS</b>The effects of some additives such as microcrystalline cellulose, beta-cyclodextrin and hydroxypropyl cellulose on drug in the preparations were examined.</p><p><b>RESULTS</b>Saponins of Panax notoginseng (PNS) was absorbed in rabbits more when administered intranasally than through other routines, and the formulations including MCC both gave high bioavailability and low irritation.</p><p><b>CONCLUSION</b>Bioavailability of Panax notoginsenosides can be increased through changing routine of administration and formulations.</p>