Effects of phenolic alkaloids of Menispermum dauricum on the hemodynamics and coronary circulation in anesthetized dog / 药学学报
Acta Pharmaceutica Sinica
;
(12): 658-660, 2003.
Article
Dans Chinois
| WPRIM
| ID: wpr-266595
ABSTRACT
<p><b>AIM</b>To observe the effect of phenolic alkaloids of Menispermum dauricum (PAMD) on the hemodynamics, coronary circulation and oxygen metabolism of the myocardium in anesthetized dogs.</p><p><b>METHODS</b>In this study, the changes of LVSP, LVEDP and +/- dp/dtmax, the flow of coronary artery and myocardial energy metabolism were measured in anesthetized dog with PAMD or NS.</p><p><b>RESULTS</b>In the anesthetized dogs, compared with pre-treatment status, PAMD at 3.5 and 7.0 mg.kg-1 caused decreases in the left ventricular systolic pressure(LVSP), +/- dp/dtmax, heart rate, the rate of oxygen utilization, the coronary and general peripheral resistance. It was found to increase myocardial oxygen and coronary flow. There were no significant change in the left ventricular end diastolic pressure (LVEDP).</p><p><b>CONCLUSION</b>PAMD can ameliorate hemodynamics, coronary circulation and myocardial metabolism.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Consommation d'oxygène
/
Pharmacologie
/
Plantes médicinales
/
Résistance vasculaire
/
Pression sanguine
/
Médicaments issus de plantes chinoises
/
Débit cardiaque
/
Répartition aléatoire
/
Chimie
/
Circulation coronarienne
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
Acta Pharmaceutica Sinica
Année:
2003
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS