Synthesis and in vitro antibacterial activities of new 3,5-disubstituted oxazolidinone compounds / 药学学报
Acta Pharmaceutica Sinica
;
(12): 754-759, 2003.
Article
Dans Chinois
| WPRIM
| ID: wpr-266610
ABSTRACT
<p><b>AIM</b>To design and synthesize new oxazolidinone antibacterial agents.</p><p><b>METHODS</b>The synthetic method reported in literature has been modified and new 3,5-disubstituted oxazolidinone compounds were synthesized on the basis of SAR reported in the literature and their antibacterial activities in vitro were determined.</p><p><b>RESULTS</b>Eighteen new objective compounds were synthesized, and their structures were determined by IR, 1HNMR and FAB-MS. Within the eighteen new objective compounds, sixteen compounds showed antibacterial activity in vitro and compound 9, 10 and 10b showed better antibacterial activities in vitro than ciprofloxacin (CIP), sultamicillin (Sul) and vancomycin (VCO). Compounds 9a and 11c have no antibacterial activity in vitro at all.</p><p><b>CONCLUSION</b>Compounds 9, 10 and 10b are worthy to be intensively studied.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pharmacologie
/
Staphylococcus aureus
/
Streptococcus
/
Relation structure-activité
/
Vancomycine
/
Structure moléculaire
/
Ciprofloxacine
/
Tests de sensibilité microbienne
/
Sulbactam
/
Chimie
langue:
Chinois
Texte intégral:
Acta Pharmaceutica Sinica
Année:
2003
Type:
Article
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