Advances in molecular mechanisms of tenascin-C in promoting tumor metastasis / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 240-244, 2015.
Article
Dans Chinois
| WPRIM
| ID: wpr-266692
ABSTRACT
Tenascin-C (TNC) is an extracellular matrix glycoprotein, which is usually highly expressed in embryonic tissues and tumor tissues, but is not expressed or just lowly expressed in mature tissues. TNC is involved in various complex signaling pathways during tumor metastasis, especially through modulating FAK, RhoA, Wnt and Notch pathways by interacting with syndecan-4, integrin α5β1, matrix metalloproteinases (MMPs) and vascular endothelial growth factor (VEGF). As a result, TNC affects epithelial mesenchymal transition, tumor cell adhesion, proliferation and angiogenesis, which eventually enhances the invasion and metastasis ability of many tumors. Further studies have demonstrated that TNC could be used as prognosis or metastasis marker of patients with malignant tumor.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Physiologie
/
Transduction du signal
/
Intégrines
/
Adhérence cellulaire
/
Ténascine
/
Matrix metalloproteinases
/
Facteur de croissance endothéliale vasculaire de type A
/
Métastase tumorale
/
Tumeurs
/
Néovascularisation pathologique
Type d'étude:
Étude pronostique
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Journal of Biomedical Engineering
Année:
2015
Type:
Article
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