Bioinformatic analysis of genes related to temporal epilepsy / 南方医科大学学报
Journal of Southern Medical University
;
(12): 180-183, 2011.
Article
Dans Chinois
| WPRIM
| ID: wpr-267643
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the genes associated with temporal epilepsy and explore the molecular mechanism of epilepsy.</p><p><b>METHODS</b>The microarray data of temporal epilepsy were downloaded from the Gene Expression Omnibus (GEO) database and analyzed by bioinformatics methods using String, KEGG and Panther databases.</p><p><b>RESULTS</b>Of all the 71 differentially expressed genes, 51 were found to encode proteins with interactions; the main biological pathways involved included neuroactive ligand-receptor interactions, MAPK signaling pathway, and calcium signaling pathway etc.</p><p><b>CONCLUSION</b>The pathogenesis of epilepsy involves multiple genes, and investigations of these genes may provide valuable insights into the mechanism of epilepsy.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Expression des gènes
/
Biologie informatique
/
Séquençage par oligonucléotides en batterie
/
Système de signalisation des MAP kinases
/
Analyse de profil d'expression de gènes
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Épilepsie temporale
/
Génétique
/
Méthodes
Limites du sujet:
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Journal of Southern Medical University
Année:
2011
Type:
Article
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