Nanometer detection of self-assembly morphology of sodium hyaluronate injection on mica / 南方医科大学学报
Journal of Southern Medical University
;
(12): 2637-2639, 2010.
Article
Dans Chinois
| WPRIM
| ID: wpr-267721
ABSTRACT
<p><b>OBJECTIVE</b>To detect the self-assembly morphology of sodium hyaluronate injection on mica using atomic force microscopy(AFM).</p><p><b>METHODS</b>Atomic force microscopy with nanometer resolution was used to observe the self-assembly morphology of different concentrations of sodium hyaluronate injection on mica at room temperature.</p><p><b>RESULTS</b>The self-assembly morphology of 0.001, 0.01, and 0.1 mg/ml sodium hyaluronate injection on mica featured piebald, reticular and dendritic structures, respectively. At 1 and 5 mg/ml, sodium hyaluronate injection displayed bacilliform and spherical structures on mica, respectively; the diameter and height of the particles of 5 mg/ml sodium hyaluronate was 197.97±78.48 nm and 30.79±18.67 nm, significantly greater than those of 0.1 mg/ml sodium hyaluronate injection (49.52±11.93 nm and 5.37±1.59 nm, respectively, P<0.05).</p><p><b>CONCLUSION</b>The self-assembly morphology of sodium hyaluronate injection on mica varies with its concentration. The piebald and reticular structure may facilitate the function of sodium hyaluronate, and the dendritic feature resembles the representative model of diffusion-limited aggregation (DLA).</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Propriétés de surface
/
Chimie
/
Microscopie à force atomique
/
Nanostructures
/
Silicates d'aluminium
/
Acide hyaluronique
Type d'étude:
Etude diagnostique
langue:
Chinois
Texte intégral:
Journal of Southern Medical University
Année:
2010
Type:
Article
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