Effect of benzene on sperm DNA / 中华男科学杂志
National Journal of Andrology
;
(12): 53-55, 2005.
Article
Dans Chinois
| WPRIM
| ID: wpr-267757
ABSTRACT
<p><b>OBJECTIVE</b>To assess the effect of benzene on sperm DNA.</p><p><b>METHODS</b>Twenty-seven workers exposed to benzene for over two years were included in the experiment group and 35 unexposed ones were chosen as controls. Damage by benzene on sperm DNA was detected by modified single cell gel electrophoresis (SCGE).</p><p><b>RESULTS</b>The benzene concentration in the air of the workplace of the exposed workers was (86.49 +/- 2.83) mg/m3, twice that of the national maximum allowance (40 mg/cm3). Urinary, trans-muconic acid in the exposed group was (1.40 +/- 0.62) mg/L (n = 27), significantly higher than that of the controls [(0.82) +/- 0.16) mg/L, n = 35]. After SCGE, the percentage of head DNA in the exposed group [(70.18% +/- 7.36%, n = 13 ] was significantly lower than that of the controls (90.62% +/- 2.94%, n = 16), P < 0.001.</p><p><b>CONCLUSION</b>Higher concentration of benzene could cause damage to the sperm DNA of the workers exposed to it.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Spermatozoïdes
/
Benzène
/
Altération de l'ADN
/
Enquêtes et questionnaires
/
Exposition professionnelle
/
Test des comètes
/
Polluants atmosphériques d'origine professionnelle
/
Toxicité
Limites du sujet:
Adulte
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
National Journal of Andrology
Année:
2005
Type:
Article
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