Apoptosis and the expression of Bax and Bcl-2 in the penis of diabetic rats / 中华男科学杂志
National Journal of Andrology
;
(12): 844-848, 2004.
Article
Dans Chinois
| WPRIM
| ID: wpr-267799
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between apoptosis and the expression of Bcl-2 and Bax in the penis cavernosal tissues of diabetic rats.</p><p><b>METHODS</b>Fifty male adult Wistar rats were divided into two groups 10 as normal control and 40 used to induce diabetes by intravenous injection of alloxan (AXN) (50 mg/kg). After 8 weeks, their penises were harvested. Apoptosis was evaluated by means of terminal deoxynucleotidyl transferase mediated d-UTP nick end labeling (TUNEL). Immunohistochemistry was employed to detect the protein of Bcl-2 and Bax.</p><p><b>RESULTS</b>Compared with those in the control group, apoptotic cells were more in number (P<0.01) and the expression of Bcl-2 was absent in the penis cavernosal tissues of the diabetic rats. However, there was upregulation of Bax and decrease in Bcl-2/Bax ratio in the diabetic group.</p><p><b>CONCLUSION</b>The high rate of apoptosis in diabetic rats may play a role in the pathophysiology of erectile dysfunction. The change in Bcl-2 and Bax activities may be responsible for apoptosis in diabetic penis erectile tissues.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Pénis
/
ADN tumoral
/
Expression des gènes
/
Rat Wistar
/
Apoptose
/
Protéines proto-oncogènes c-bcl-2
/
Diabète expérimental
/
Modèles animaux de maladie humaine
/
Protéine Bax
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
National Journal of Andrology
Année:
2004
Type:
Article
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