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Influence of androgen deprivation therapy on bone mineral density in men with prostate cancer / 中华男科学杂志
National Journal of Andrology ; (12): 761-763, 2004.
Article Dans Chinois | WPRIM | ID: wpr-267818
ABSTRACT
<p><b>OBJECTIVE</b>To determine the influence of androgen deprivation therapy (ADT) on bone mineral density (BMD) in men with prostate cancer.</p><p><b>METHODS</b>Forty-nine men with prostate cancer underwent BMD determination and then were classified into two groups non-ADT group (21 cases), who were about to receive ADT, and ADT group (28 cases), who had received ADT for more than 1 year. BMD was determined by dual energy X-ray absorptiometry (DEXA) in the lumbar spine (L2-4) and femoral neck in all the patients. The Age-Matched Z scores were used as the reference standard for controlling the difference of age, sex and weight.</p><p><b>RESULTS</b>Thirteen (62%) of the non-ADT group and 23 (82%) of the ADT group fulfilled the BMD criteria for osteopenia or osteoporosis. Z scores for the Age-Matched control in the lumbar spine and femoral neck were -(0.9 +/- 0.7) and -(0.6 +/- 0.5) in the non-ADT group, and -(1.8 +/- 1.1) and -(1.6 +/- 1.0) in the ADT group, respectively (P<0.01). The men of the ADT group had significantly lower BMD in the lumbar spine and femoral neck than those of the non-ADT group.</p><p><b>CONCLUSION</b>Pre-existing osteopenia and osteoporosis are common in men with prostate cancer before ADT. ADT is significantly associated with the loss of BMD and the evaluation of BMD is necessary before ADT for men with prostate cancer.</p>
Sujets)
Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Ostéoporose / Tumeurs de la prostate / Chirurgie générale / Orchidectomie / Absorptiométrie photonique / Densité osseuse / Utilisations thérapeutiques / Antagonistes des androgènes Limites du sujet: Adulte très âgé / Aged80 / Humains / Mâle langue: Chinois Texte intégral: National Journal of Andrology Année: 2004 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Ostéoporose / Tumeurs de la prostate / Chirurgie générale / Orchidectomie / Absorptiométrie photonique / Densité osseuse / Utilisations thérapeutiques / Antagonistes des androgènes Limites du sujet: Adulte très âgé / Aged80 / Humains / Mâle langue: Chinois Texte intégral: National Journal of Andrology Année: 2004 Type: Article