Relationship between mitochondrial DNA and myelodysplastic syndromes - review / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 712-716, 2008.
Article
Dans Chinois
| WPRIM
| ID: wpr-267905
ABSTRACT
Mitochondria is the main place of biological oxidation and energy transform. Mitochondrial DNA encodes the complex of respiratory chain in mitochondria and its mutation can cause a series of human disease. Mitochondrial DNA mutation which observed in myelodysplastic syndrome (MDS) patients cause the MDS by the mechanism of iron metabolism disorder, gene instability and hemopoietic progenitor cell apoptosis. In this review the characteristics of mitochondrial DNA structure, the mitochondrial DNA mutation and the possible mechanism of mitochondrial DNA mutation in pathogenesis of MDS were summarized.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Syndromes myélodysplasiques
/
ADN mitochondrial
/
Mutation ponctuelle
/
Génétique
/
Anémie sidéroblastique
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Journal of Experimental Hematology
Année:
2008
Type:
Article
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