Bulky DNA adducts in human sperm correlate with semen parameters and sperm apoptosis / 中华男科学杂志
National Journal of Andrology
;
(12): 902-906, 2013.
Article
Dans Chinois
| WPRIM
| ID: wpr-268034
ABSTRACT
<p><b>OBJECTIVE</b>To explore the correlation of sperm polycyclic aromatic hydrocarbons (PAH)-DNA adducts with semen quality and sperm apoptosis.</p><p><b>METHODS</b>We collected semen samples from 433 infertile Chinese men, detected sperm PAH-DNA adducts using immunofluorescence staining and flow cytometry, and determined the rate of sperm apoptosis by TUNEL.</p><p><b>RESULTS</b>Multiple linear regression analysis showed that the level of sperm PAH-DNA adducts was correlated negatively with sperm concentration (beta = -0.632), total sperm count (beta = -0.830) and sperm motility (beta = -9.647), but positively with the rate of sperm apoptosis (beta = 0.130).</p><p><b>CONCLUSION</b>Sperm PAH-DNA adducts are evidently correlated with semen quality and sperm apoptosis, and play an important role in the evaluation of male productivity.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Hydrocarbures aromatiques polycycliques
/
Sperme
/
Numération des spermatozoïdes
/
Spermatozoïdes
/
Chimie
/
Apoptose
/
Adduits à l'ADN
/
Analyse du sperme
/
Infertilité masculine
Limites du sujet:
Adulte
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
National Journal of Andrology
Année:
2013
Type:
Article
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