Design and synthesis of aralkyl-ketone piperazine derivatives and their antalgic activities / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1166-1175, 2007.
Article
Dans Chinois
| WPRIM
| ID: wpr-268210
ABSTRACT
To synthesize aralkyl-ketone piperazine derivatives as analgesic agents, the N atom of the one side of piperazine ring is protected by formyl group firstly, then the unprotected N atom is alkylated to prepare aralkyl-ketone piperazine derivatives. Their analgesic biological activities were well studied by mice writhing model, rat hot plate model and rat tail flick model. Sixty four compounds were synthesized and pharmacological tests in vivo revealed these compounds have potent analgesic activities, especially compound I12, I14, I14 I21 and I37. These four compounds are more worthy for further research.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pharmacologie
/
Pipérazines
/
Mesure de la douleur
/
Structure moléculaire
/
Répartition aléatoire
/
Rat Sprague-Dawley
/
Analgésiques
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
Acta Pharmaceutica Sinica
Année:
2007
Type:
Article
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