Recent progress in the study of HIV-1 transcription factor NF-kappaB and its inhibitors / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1007-1012, 2007.
Article
Dans Chinois
| WPRIM
| ID: wpr-268538
ABSTRACT
Human immunodeficiency virus type 1 (HIV-1) transcription is a crucial step in the viral replication cycle, which is considered to be a potential target for inhibition of HIV-1 replication. Among the factors involved in this step, the cellular protein nuclear factor NF-kappaB is the most powerful inducer of HIV-1 transcription. HIV-1 transcription is initiated by the binding of NF-kappaB to the enhancer region in the long terminal repeat (LTR) of HIV-1. Several compounds suppress HIV-1 transcription through the inhibition of NF-kappaB activation. The mechanisms of NF-kappaB in the transcription of HIV-1 and progress of the current inhibitors of NF-kappaB are reviewed.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pharmacologie
/
Transcription génétique
/
Réplication virale
/
Répétition terminale longue du VIH
/
Facteur de transcription NF-kappa B
/
VIH-1 (Virus de l'Immunodéficience Humaine de type 1)
/
Agents antiVIH
/
Protéines I-kappa B
/
I-kappa B Kinase
/
Inhibiteur alpha de NF-KappaB
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Acta Pharmaceutica Sinica
Année:
2007
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS