HERG K+ channel, the target of anti-arrhythmias drugs / 药学学报
Acta Pharmaceutica Sinica
;
(12): 687-691, 2007.
Article
Dans Chinois
| WPRIM
| ID: wpr-268595
ABSTRACT
Rapidly activating component of delayed rectifier potassium current (I(Kr)) plays a key role in the repolarization phase of cardiac action potential. Human ether-a-go-go-related gene (HERG) encodes the alpha subunit of this potassium channel. Mutations of HERG gene induce genetic long QT syndrome (LQTS). Furthermore, I(Kr)/HERG is the target of some drugs which may cause cardiac QT interval prolongation. Some other drugs with different chemical structures also may block the channel and prolong QT interval, which even developed into acquired arrhythmias. This review summarized the recent progress of structure, gating mechanisms and functions of I(Kr)/HERG channel, I(Kr)/HERG related arrhythmias, interaction between K+ channel and drugs, and strategies of grading-up the I(Kr)/HERG target.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pharmacologie
/
Troubles du rythme cardiaque
/
Syndrome du QT long
/
Ouverture et fermeture des portes des canaux ioniques
/
Chimie
/
Inhibiteurs des canaux potassiques
/
Utilisations thérapeutiques
/
Traitement médicamenteux
/
Canaux potassiques éther-à-go-go
/
Génétique
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Acta Pharmaceutica Sinica
Année:
2007
Type:
Article
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