Clinicopathologic and immunohistochemical study of atypical teratoid/rhabdoid tumor of central nervous system / 中华病理学杂志
Chinese Journal of Pathology
;
(12): 458-461, 2006.
Article
Dans Chinois
| WPRIM
| ID: wpr-268933
ABSTRACT
<p><b>OBJECTIVE</b>To study the clinicopathologic features and differential diagnosis of atypical teratoid/rhabdoid tumor (AT/RT) occurring in the central nervous system.</p><p><b>METHODS</b>Two cases of AT/RT were studied by hematoxylin-eosin, reticulin and immunohistochemical staining. The clinical and pathologic features were analyzed and the literatures reviewed.</p><p><b>RESULTS</b>Histologically, AT/RT was characterized by the presence of rhabdoid cells associated with various degrees of primitive neuroectodermal, epithelial or mesenchymal differentiation. Abundant reticulin fibers and a complex immunophenotype were observed. The tumor cells were positive for vimentin, CD99, epithelial membrane antigen, cytokeratin, glial fibrillary acidic protein, S-100 protein, neurofilament, desmin and smooth muscle actin. They were negative for synaptophysin, MyoD1, placental alkaline phosphatase and HMB45.</p><p><b>CONCLUSIONS</b>AT/RT is a highly malignant tumor occurring in the central nervous system. It manifests mainly in children and occasionally in adults. The tumor is characterized by a heterogeneous histologic and immunohistochemical phenotype. It needs to be distinguished from a number of central nervous system tumors, including medulloblastoma, primitive neuroectodermal tumor, germ cell neoplasm and rhabdoid meningioma.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Tératome
/
Vimentine
/
Tumeurs du cerveau
/
Immunohistochimie
/
Protéines S100
/
Antigènes CD
/
Molécules d'adhérence cellulaire
/
Chimie
/
Actines
Limites du sujet:
Adulte
/
Enfant d'âge préscolaire
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Chinese Journal of Pathology
Année:
2006
Type:
Article
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