Study on the pharmacological mechanism of analgesic effect of injection stauntoniae / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 39-43, 2006.
Article
Dans Chinois
| WPRIM
| ID: wpr-269043
ABSTRACT
<p><b>OBJECTIVE</b>To study the effects of Injection Stauntoniae (IS) on voltage-gated sodium currents in dorsal root ganglion neurons and analyze its pharmacological mechanism of blocking the nerve conduction and anal gesic action.</p><p><b>METHODS</b>Whole-cell patch-clamp recordings were performed in acutely isolated rat dorsal root ganglion neurons and the effects of 10% , 25% and 50 % IS on voltage-gated sodium currents were observed.</p><p><b>RESULTS</b>IS inhibited the peak sodium currents in dorsal root ganglion neurons in a dose-dependent way and affected the activation and inactivation process of the channels.</p><p><b>CONCLUSION</b>The analgesic effect of IS was presumably caused by modulation of voltage-gated sodium channels in primary sensory neurons besides structure destruction of myelin sheath and axon membrane.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pharmacologie
/
Médicaments issus de plantes chinoises
/
Canaux sodiques
/
Fougères
/
Ganglions sensitifs des nerfs spinaux
/
Analgésiques
/
Injections
/
Métabolisme
/
Neurones
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
Chinese Journal of Integrated Traditional and Western Medicine
Année:
2006
Type:
Article
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