Effects of Ginkgo biloba extract (ginaton) on mRNA expression of bcl-2 and bcl-xL in myocardium of patients underwent hypothermic cardiopulmonary bypass / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 256-258, 2007.
Article
Dans Chinois
| WPRIM
| ID: wpr-269085
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of Ginkgo biloba extract (Ginaton) on bcl-2 and bcl-xL mRNA expression in the myocardium of patients underwent hypothermic cardiopulmonary bypass (CPB).</p><p><b>METHODS</b>Thirty congenital heart disease patients were randomly assigned to 2 groups, the control group and the treated group. Patients in both groups received St. Thomas' cardioplegic solution via radix aortae, while Ginaton (0.5 mg/kg) was added in the treated group. Cardiac surgery was started after complete heart arrest. Myocardium was taken before the aorta ascendens was unblocked and mRNA expression of bcl-2 and bcl-xL in the ventricular tissue was detected by RT-PCR.</p><p><b>RESULTS</b>The gene expressions of bcl-2 and bcl-xL were significantly higher in the treated group than those in the control group (P < 0.05).</p><p><b>CONCLUSION</b>Ginaton could promote the mRNA expressions of the antiapoptotic gene bcl-2 and bcl-xL in myocardium of patients underwent CI'PB.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pharmacologie
/
Chirurgie générale
/
ARN messager
/
Médicaments issus de plantes chinoises
/
Pontage cardiopulmonaire
/
Expression des gènes
/
Chimie
/
Feuilles de plante
/
Protéines proto-oncogènes c-bcl-2
/
Ginkgo biloba
Limites du sujet:
Enfant
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Chinese Journal of Integrated Traditional and Western Medicine
Année:
2007
Type:
Article
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