Experimental study on effect of Shenling Yigan Granule in antagonizing duck hepatitis B virus / 中国中西医结合杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the viral inhibitory effect of Shenling Yigan Granule (SYG) on duck hepatitis B virus (DHBV) in vivo.</p><p><b>METHODS</b>Chongqing ducks infected with DHBV were used. They were randomly divided into five groups, the small-, medium- and high-dose (1.6 g/kg, 3.2 g/kg, 6.4 g g/kg) SYG groups, the lamivudine positive control group, and the model group. The changes of serum DHBV-DNA, DHB-sAg contents and hepatic pathology were observed.</p><p><b>RESULTS</b>The serum content of DHBV-DNA in the three SYG groups and the positive control group was significantly decreased (P < 0.05), while it was rebounded in the latter at day 7 after stopped lamivudine administration. The change of DHBsAg level was insignificantly in all groups. And the hepatic pathological change in the SYG groups and positive control group was slighter than that in the model control group, but showed insignificant difference in comparison between the SYG groups and the model group (P > 0.05).</p><p><b>CONCLUSION</b>SYG has certain in vivo inhibitory effects on DHBV-DNA.</p>