Experimental study on treatment of immune ulcerative colitis in mice by Changlu Enema / 中国中西医结合杂志

ABSTRACT

<p><b>OBJECTIVE</b>To observe the therapeutic effect of Chinese compound, Changlu Enema (CE), on immune ulcerative colitis (UC) in mice.</p><p><b>METHODS</b>Mice were randomly divided into the normal group, the model group, the CE high dose (CE-H) and low dose (CE-L) group and the salicylazosulfapyridine (SASP) group. All mice, except those in the normal group, were made into UC model by colonic mucosa protein immunization. After 21 days of medication, the changes of UC activity index and body weight in mice were observed, and the condition of colonic inflammation and histomorphological changes in colonic tissue were observed also.</p><p><b>RESULTS</b>UC activity index was lower and body weight was higher in the two CE groups than those in the model group respectively, showing significant difference (P < 0.05 or P < 0.01); pathological examination showed the pathological changes and inflammatory response in colonic tissue were relieved significantly after treatment, and the improvement in the CE-H group was better than that in the SASP group.</p><p><b>CONCLUSION</b>TCM compound CE is markedly effective in treating UC rats.</p>