In vitro Antagonism between Cefotaxime and Anti-Rickettsial Antibiotics against Orientia tsutsugamushi / 감염과화학요법
Infection and Chemotherapy
;
: 189-193, 2014.
Article
Dans Anglais
| WPRIM
| ID: wpr-27053
ABSTRACT
We have investigated the in vitro antimicrobial effects of antibiotic combinations against Orientia tsutsugamushi, the causative agent of scrub typhus. ECV304 cells were infected with the Boryong strain of O. tsutsugamushi and incubated in a medium containing doxycycline (4 microg/mL), azithromycin (0.5 microg/mL), rifampin (4 microg/mL), ciprofloxacin (25 microg/mL), gentamicin (5 microg/mL), cefotaxime (2 microg/mL), or combinations of these agents for 7 days, after which immunofluorescent staining for O. tsutsugamushi was performed. The percentages of infective foci in cultures containing antibiotics compared to those in cultures without antibiotics were 6.2% for doxycycline, 9.6% for azithromycin, 8.8% for rifampin, 96.6% for cefotaxime, 29.7% for doxycycline plus cefotaxime, 23.6% for azithromycin plus cefotaxime, and 41.4% for rifampin plus cefotaxime. These findings show an in vitro antagonism between anti-rickettsial agents and cefotaxime against O. tsutsugamushi. These results suggest that the efficacy of antibiotic combinations involving cefotaxime for the treatment of patients with scrub typhus, particularly those with severe pneumonia, needs to be investigated.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pneumopathie infectieuse
/
Orientia tsutsugamushi
/
Rifampicine
/
Fièvre fluviale du Japon
/
Gentamicine
/
Ciprofloxacine
/
Céfotaxime
/
Doxycycline
/
Azithromycine
/
Antagonisme des médicaments
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Infection and Chemotherapy
Année:
2014
Type:
Article
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