Androgenic effect of Mondia whitei roots in male rats / 亚洲男科学杂志(英文版)
Asian Journal of Andrology
;
(6): 269-272, 2004.
Article
Dans Anglais
| WPRIM
| ID: wpr-270896
ABSTRACT
<p><b>AIM</b>To determine the effect of the aqueous extract of Mondia whitei (Periplocaceae) roots on testosterone production and fertility of male rats.</p><p><b>METHODS</b>Adult male Wistar rats were used. In the acute study, 20 rats were randomly divided into 5 groups of 4 animals each. Four treated groups were administered orally a single dose of Mondia whitei (400 mg/kg) and the controls received a similar amount of distilled water. One group of animals were sacrificed by cervical dislocation 1, 2, 4 and 6 h after treatment, respectively. The controls were sacrificed at 6 h. Testicular testosterone was determined by radioimmunoassay. In the chronic study, 28 rats were divided at random into 4 groups of 7 animals each Groups 1, 2 and 3 were given orally the plant extract (400 mg.kg(-1).day(-1)) for 2, 4 and 8 days, respectively. The animals of Groups 1 and 2 were sacrificed 24 hours after the last dosing. The controls (Group 4) received the same amount of distilled water for 8 days. The fertility was assessed only in Groups 3 and 4 and after that, the animals were sacrificed and the epididymal sperm density, the serum testosterone and the testicular testosterone and 17 beta-estradiol were assayed. The serum, testicular and epidydimal protein contents were also determined.</p><p><b>RESULTS</b>In the acute treatment groups, the serum and testicular concentrations of testosterone remained unchanged at all the time points. Chronic treatment for 8 days induced a significant increase in the testicular weight, the serum and testicular testosterone, the testicular protein content and the sperm density (P < 0.05-0.01), but did not affect the accessory gland weights, the serum protein contents, the testicular concentration of 17beta -estradiol and the fertility compared to the controls.</p><p><b>CONCLUSION</b>Mondia whitei root extract possesses an androgenic property.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Taille d'organe
/
Pharmacologie
/
Numération des spermatozoïdes
/
Testicule
/
Testostérone
/
Sang
/
Extraits de plantes
/
Rat Wistar
/
Racines de plante
/
Gentiana
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Asian Journal of Andrology
Année:
2004
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS