Result of phase II clinical trial of herceptin in advanced Chinese breast cancer patients / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 581-583, 2003.
Article
Dans Chinois
| WPRIM
| ID: wpr-271075
ABSTRACT
<p><b>OBJECTIVE</b>To observe the clinical efficacy and adverse effects of herceptin for advanced Chinese breast cancer patients.</p><p><b>METHODS</b>Thirty-one pathologically proved advanced breast cancer women were treated by herceptin. In the first week, a loading dose 4 mg/kg was administered by intravenous infusion and from the second week, a routine dose of 2 mg/kg was given every week for at least 3 months.</p><p><b>RESULTS</b>There were 2 CR, 6 PR, 7 SD, and 16 PD among 31 patients after treatment by herceptin, the response rate being 25.8%. In factors influencing the prognosis, age and general condition were factors favoring the results, and pathological type, site of metastasis, grade of her-2 over expression and prior treatment were irrelevant to the results. The adverse effects were mild but different from those of the common anticancer drugs.</p><p><b>CONCLUSION</b>Herceptin is effective and well tolerated by the Chinese breast cancer patients.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Tumeurs du sein
/
Utilisations thérapeutiques
/
Traitement médicamenteux
/
Anticorps monoclonaux humanisés
/
Trastuzumab
/
Anticorps monoclonaux
Type d'étude:
Étude pronostique
Limites du sujet:
Adulte
/
Adulte très âgé
/
Femelle
/
Humains
langue:
Chinois
Texte intégral:
Chinese Journal of Oncology
Année:
2003
Type:
Article
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