Randomized trial on adjuvant radiotherapy for postoperative breast cancer: a 15 year experience / 中华肿瘤杂志

ABSTRACT

<p><b>OBJECTIVE</b>To evaluate the long term effects of adjuvant radiotherapy for postoperative breast cancer.</p><p><b>METHODS</b>From 1985 to 1986, 162 patients with operable breast cancer were randomly given adjuvant radiotherapy according to clinical stage and involving condition of axillary lymph nodes (LN). The radiotherapy group (RG) was irradiated in the supraclavicular area and/or internal mammary area to 50 Gy, while the control group (CG) was not.</p><p><b>RESULTS</b>The overall 5-, 10- and 15-year survival rates of the RG were 72.0%, 56.1% and 54.3%, while they were 66.3%, 51.3% and 49.4% in the CG (P > 0.05). Clinical stage I-IIIa and positive or negative LN showed no significant difference in the two groups. But in patients with LN(+) > or = 4, the 5-, 10- and 15-year survival rates of the RG were 55.6%, 38.9% and 37.1%, which were higher than the CG of 29.0%, 16.1% and 16.1% (P < 0.05).</p><p><b>CONCLUSION</b>Adjuvant radiotherapy can improve the prognosis for breast cancer patients with LN(+) > or = 4, but not for LN(-).</p>