Effects of electrode on epileptogenic focus potential and expressions of the beta subunit of ATP synthase in rats with penicillin-induced epilepsy / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 287-290, 2012.
Article
Dans Chinois
| WPRIM
| ID: wpr-271788
ABSTRACT
The changed process of bioenergy and the effects of electrode interfering on penicillin-induced epileptic brains in epileptic seizures rats were investigated. Fifty Sprague-Dawley (SD) rats were randomly divided into 4 groups, i. e. normal saline control group (group A), penicillin model group (group B), metal electrode interfere group (group C) and insulated electrode interfere group (group D). The epileptogenic potential and the expressions of the beta subunit of-ATP synthase( ATP5B) in hippocampal neurons were measured. The epileptogenic foucus potential and expressions of ATP5B in hippocampus neurons showed that the trend increased at first and decreased implantation of later, and the implantation of metal electrodes decreased the epileptogenic foucus potential at corresponding time point, but had no effect on the expressions of ATP5B. The change of epileptogenic focus potential was reduced by implantation of metal electrode, possibly due to the alteration of corrosponding bioenergy metabolism which had participated in the process of epileptic seizure.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pénicillines
/
Rat Sprague-Dawley
/
Mitochondrial Proton-Translocating ATPases
/
Électrodes
/
Métabolisme énergétique
/
Épilepsie
/
Génétique
/
Hippocampe
/
Métabolisme
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
Journal of Biomedical Engineering
Année:
2012
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS