Study rat nephrotoxicity of Longdan Xiegan Tang / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 785-788, 2004.
Article
Dans Chinois
| WPRIM
| ID: wpr-272799
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the nephrotoxocity of Longdan Xiegan Tang in rats, and to test its safety.</p><p><b>METHOD</b>Sprague-Dauley rats were given Longdan Xiegan Tang 4.5 mL x (100 mg)(-1) Bid for thirty days, and the control group was given NS. MTP, BUN, Cr, MDA, MTP/Ucr and SOD were measured on 1st, 2nd, 3rd, 4th week. The kidney tissues were viewed with light microscopy and electron microscope.</p><p><b>RESULT</b>MTP and MTP/Ucr were obviously higher than controls ( P < 0.01), and the other index had no difference (P > 0.05). No remarkable structural change could been seen with light microscopy, but with electron microscope we could find that the basal membranes were thickened and some of foot process were infused.</p><p><b>CONCLUSION</b>Longdan Xiegan Tang will result in injury of kidney function.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Plantes médicinales
/
Protéinurie
/
Superoxide dismutase
/
Membrane basale
/
Sang
/
Azote uréique sanguin
/
Médicaments issus de plantes chinoises
/
Chimie
/
Rat Sprague-Dawley
/
Magnoliopsida
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
China Journal of Chinese Materia Medica
Année:
2004
Type:
Article
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