Effect of Xuebijing injection on peripheral T-lymphocyte subpopulations in patients with severe trauma / 中华创伤杂志(英文版)
Chinese Journal of Traumatology
;
(6): 72-76, 2010.
Article
Dans Anglais
| WPRIM
| ID: wpr-272945
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect and clinical significance of Xuebijing injection on peripheral T-lymphocyte subpopulations in patients with severe trauma.</p><p><b>METHODS</b>Thirty-three patients with severe trauma were randomly divided into a control group (n=16) and a treatment group (n=17). The patients of two groups were all treated conventionally, and the only difference was that Xuebijing injection was given to patients of the treatment group. The CD4+ and CD8+ subpopulations of T-lymphocyte in the peripheral blood were detected respectively on admission, 3rd and 5th days after trauma by double antibody labeling and flow cytometry.</p><p><b>RESULTS</b>The CD4+ T-lymphocytes and CD4+/CD8+ ratio of peripheral blood in patients with severe trauma decreased markedly on the 3rd and 5th days after trauma. Furthermore, compared with control group, the peripheral CD4+ T-lymphocytes and CD4+/CD8+ ratio of treatment group renewed obviously on the 5th day after trauma, and showed statistical differences (P<0.05).</p><p><b>CONCLUSION</b>In the treatment of patients with severe trauma, the early use of Xuebijing injection is effective in correcting disorder or suppression of T-lymphocyte subpopulations regulating network, and promoting a more balanced profile of immunologic function.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pronostic
/
Plaies et blessures
/
Médicaments issus de plantes chinoises
/
Sous-populations de lymphocytes T
/
Rapport CD4-CD8
/
Utilisations thérapeutiques
/
Traitement médicamenteux
/
Allergie et immunologie
/
Injections
Type d'étude:
Étude pronostique
Limites du sujet:
Adulte
/
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Chinese Journal of Traumatology
Année:
2010
Type:
Article
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