Propofol depresses c -fos expression of NOS neurons in the spinal cord of rats with inflammatory pain / 生理学报
Acta Physiologica Sinica
;
(6): 60-64, 2002.
Article
Dans Chinois
| WPRIM
| ID: wpr-272983
ABSTRACT
In formalin pain model, the effect of propofol on Fos expression in the spinal cord was examined by means of c -fos oncogene immunohistochemistry and NADPH-d histochemistry. Fos-like immunoreactive (FLI) neurons were mainly found in the ipsilateral dorsal horn after injection of formalin, some of which were FLI/NOS double-labeled neurons. Most of the FLI or FLI/NOS double-labeled neurons were observed in the medial part of lamina and the outer lamina . Before or after injection of formain, i.p. injection of propofol significantly decreased the number of FLI and FLI/NOS double-labeled neurons in all laminae (P<0.05 or P<0.01). By single i.p. injection of propofol or normal saline, few FLI neurons were found in the spinal cord. The results suggest that the antinociceptive function of propofol is possibly involved in the depression of the NOS neurons in the spinal cord.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Douleur
/
Pharmacologie
/
Moelle spinale
/
Propofol
/
Protéines proto-oncogènes c-fos
/
Rat Sprague-Dawley
/
Nitric oxide synthase
/
Formaldéhyde
/
Métabolisme
/
Neurones
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
Acta Physiologica Sinica
Année:
2002
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS