Effects of regulatory peptides on adhesion of eosinophil to bronchial epithelial cells / 生理学报
Acta Physiologica Sinica
;
(6): 43-46, 2002.
Article
Dans Chinois
| WPRIM
| ID: wpr-272986
ABSTRACT
To explore the roles of regulatory peptides in the process of various anaphylactic inflammation of the airway, we observed the influence of four peptides, i.e., vasoactive intestinal peptide (VIP), epidermal growth factor (EGF), endothelin-1 (ET-1), and calcitonin gene-related peptide (CGRP), on the adhesion of eosinophil (EOS) to unstimulated and O(3)-stressed bronchial epithelial cells (BEC). From the experiments we observed that VIP and EGF decreased EOS adherence to O(3)-stressed BEC and downregulated airway inflammation; ET-1 and CGRP increased the adhesion of EOS to BEC in the inflammatory process; and CGRP aggravated O(3)-stressed reactions. The effects of ET-1 and CGRP were inhibited by W(7)and H(7). Anti-ICAM-1 antibody inhibited the adhesion of EOS to BEC, which brings to light that EOS adherence to BEC may be related to the expression of ICAM-1 of BEC.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pharmacologie
/
Physiologie
/
Bronches
/
Peptide vasoactif intestinal
/
Adhérence cellulaire
/
Cellules cultivées
/
Molécule-1 d'adhérence intercellulaire
/
Endothéline-1
/
Biologie cellulaire
/
Allergie et immunologie
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
Acta Physiologica Sinica
Année:
2002
Type:
Article
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