Analysis of Megakaryocytes and Platelet Parameters of ITP Patients / 中国实验血液学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the value of bone marrow megakaryocyte (BMK) and peripheral platelet parameter changes in differential diagnosis of idiopathic thrombocytopenic purpura (ITP).</p><p><b>METHODS</b>The 91 patients were divided into 2 groups: ITP group (46 cases) and non-ITP group (45 cases), while 48 healthy volunteers were used as healthy controls. The parameters of BMK and peripheral platelets of ITP and non-ITP patients, and parameters of peripheral platelets of healthy controls were detected and compared.</p><p><b>RESULTS</b>As compared with non-ITP group, the BMK count in ITP group obviously increased, including the gramlar MK and proo-MK, while the MK producing platelets obviously dicreased with statistical difference (P < 0.01); the platelet parameters in 2 groups did not show significant difference (P > 0.05). As compared with healthy control group, the platelet level and PCT of peripheral blood in ITP group significantly decreased (P < 0.01).</p><p><b>CONCLUSION</b>The BMK level and platelet parameters, especially the platelet count and PCT have clinical value for differential diagnosis of ITP to a certain degree.</p>