Your browser doesn't support javascript.
loading
Genomic Instability in Acute Transformation of Chronic Myelogenous Leukemia / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 1199-1202, 2015.
Article Dans Chinois | WPRIM | ID: wpr-274066
ABSTRACT
Chronic myeloid leukemia (CML) is a myeloproliferative disorder, characterized by excessive proliferation of myeloid cells. CML patients in early phase [also known as chronic phase (CP)] usually respond to treatment with tyrosine kinase inhibitors (TKI), some patients respond initially to TKI, but later become resistant, then resulting in the transformation from CP to more advanced phase, which were subclassified as either accelerated phase or blastic phase. At present, the molecular mechanisms of CML have been not yet clear, and acute transformation has been not fully understood, studies have shown that genomic instability promotes the acute conversion of CML. This review discusses the molecular mechanisms leading to the transformation of CML, and some therapeutic approaches.
Sujets)
Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Leucémie myéloïde chronique BCR-ABL positive / Crise blastique / Résistance aux médicaments antinéoplasiques / Instabilité du génome Limites du sujet: Humains langue: Chinois Texte intégral: Journal of Experimental Hematology Année: 2015 Type: Article

Documents relatifs à ce sujet

MEDLINE

...
LILACS

LIS

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Leucémie myéloïde chronique BCR-ABL positive / Crise blastique / Résistance aux médicaments antinéoplasiques / Instabilité du génome Limites du sujet: Humains langue: Chinois Texte intégral: Journal of Experimental Hematology Année: 2015 Type: Article