Effect of Ikaros in B Cell Acute Lymphoblastic Leukemia / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 1194-1198, 2015.
Article
Dans Chinois
| WPRIM
| ID: wpr-274067
ABSTRACT
The Ikaros - a DNA-binding zinc finger protein, acting as a regulator of chromatin remodeling and gene transcription, is crucial for regulating the development and function of the immune system and acting as a master regulator of hematopoietic differentiation. Function-loss mutations of IKZF1, gene encoding Ikaros are frequent in B cell acute lymphoblastic leukemia (B-ALL) and are associated with a poor prognosis. This review briefly summarizes the available data regarding the structure and function of Ikaros, the role of Ikaros as a tumor suppressor in B-ALL, and its regulation mechanism.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Lymphocytes B
/
Différenciation cellulaire
/
Gènes suppresseurs de tumeur
/
Facteur de transcription Ikaros
/
Leucémie-lymphome lymphoblastique à précurseurs B et T
/
Mutation
Type d'étude:
Étude pronostique
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Journal of Experimental Hematology
Année:
2015
Type:
Article
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