Effect of botulinum toxin-A on secretion of parasympathetic denervated rabbit submandibular gland / 中华口腔医学杂志
Chinese Journal of Stomatology
;
(12): 548-552, 2009.
Article
Dans Chinois
| WPRIM
| ID: wpr-274531
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of botulinum toxin-A (BTX-A) on secretion of parasympathetic denervated rabbit submandibular gland.</p><p><b>METHODS</b>Twenty-four rabbits were divided into 3 groups control (n = 4), parasympathetic denervated submandibular gland (n = 4), and parasympathetic denervated submandibular gland with 5 U BTX-A injection (n = 16). Secretion flow was measured by Schirmer test. Composition of saliva was detected by biochemical method.</p><p><b>RESULTS</b>Secretion of parasympathetic denervated submandibular gland increased by 139.0% in rest time (P < 0.01), but decreased by 64.2% in feeding time (P < 0.01) compared with controls. Secretion of submandibular gland decreased in rest time 1, 2, 4, and 12 weeks after BTX-A injection compared with that of parasympathetic denervated submandibular gland without injection (P < 0.05), which was also the same in feeding time 1 and 2 week after injection (P < 0.05). The concentrations of amylase, sodium, potassium, chloride and protein of saliva were not changed after BTX-A injection.</p><p><b>CONCLUSIONS</b>BTX-A could decrease the secretion of parasympathetic denervated submandibular gland.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pharmacologie
/
Salive
/
Glande submandibulaire
/
Toxines botuliniques de type A
/
Sécrétions corporelles
/
Dénervation
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
Chinese Journal of Stomatology
Année:
2009
Type:
Article
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