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Effect of botulinum toxin-A on secretion of parasympathetic denervated rabbit submandibular gland / 中华口腔医学杂志
Chinese Journal of Stomatology ; (12): 548-552, 2009.
Article Dans Chinois | WPRIM | ID: wpr-274531
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of botulinum toxin-A (BTX-A) on secretion of parasympathetic denervated rabbit submandibular gland.</p><p><b>METHODS</b>Twenty-four rabbits were divided into 3 groups control (n = 4), parasympathetic denervated submandibular gland (n = 4), and parasympathetic denervated submandibular gland with 5 U BTX-A injection (n = 16). Secretion flow was measured by Schirmer test. Composition of saliva was detected by biochemical method.</p><p><b>RESULTS</b>Secretion of parasympathetic denervated submandibular gland increased by 139.0% in rest time (P < 0.01), but decreased by 64.2% in feeding time (P < 0.01) compared with controls. Secretion of submandibular gland decreased in rest time 1, 2, 4, and 12 weeks after BTX-A injection compared with that of parasympathetic denervated submandibular gland without injection (P < 0.05), which was also the same in feeding time 1 and 2 week after injection (P < 0.05). The concentrations of amylase, sodium, potassium, chloride and protein of saliva were not changed after BTX-A injection.</p><p><b>CONCLUSIONS</b>BTX-A could decrease the secretion of parasympathetic denervated submandibular gland.</p>
Sujets)
Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Pharmacologie / Salive / Glande submandibulaire / Toxines botuliniques de type A / Sécrétions corporelles / Dénervation Limites du sujet: Animaux langue: Chinois Texte intégral: Chinese Journal of Stomatology Année: 2009 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Pharmacologie / Salive / Glande submandibulaire / Toxines botuliniques de type A / Sécrétions corporelles / Dénervation Limites du sujet: Animaux langue: Chinois Texte intégral: Chinese Journal of Stomatology Année: 2009 Type: Article