Silica-coated ethosome as a novel oral delivery system for enhanced oral bioavailability of curcumin / 药学学报
Acta Pharmaceutica Sinica
; (12): 1541-1547, 2012.
Article
de Zh
| WPRIM
| ID: wpr-274625
Bibliothèque responsable:
WPRO
ABSTRACT
The aim of this study is to investigate the feasibility of silica-coated ethosome as a novel oral delivery system for the poorly water-soluble curcumin (as a model drug). The silica-coated ethosomes loading curcumin (CU-SE) were prepared by alcohol injection method with homogenization, followed by the precipitation of silica by sol-gel process. The physical and chemical features of CU-SEs, and curcumin release were determined in vitro. The pharmacodynamics and bioavailability measurements were sequentially performed. The mean diameter of CU-SE was (478.5 +/- 80.3) nm and the polydispersity index was 0.285 +/- 0.042, while the mean value of apparent drug entrapment efficiency was 80.77%. In vitro assays demonstrated that CU-SEs were significantly stable with improved release properties when compared with curcumin-loaded ethosomes (CU-ETs) without silica-coatings. The bioavailability of CU-SEs and CU-ETs was 11.86- and 5.25-fold higher, respectively, than that of curcumin suspensions (CU-SUs) in in vivo assays. The silica coatings significantly promoted the stability of ethosomes and CU-SEs exhibited 2.26-fold increase in bioavailablity relative to CU-ETs, indicating that the silica-coated ethosomes might be a potential approach for oral delivery of poorly water-soluble drugs especially the active ingredients of traditional Chinese medicine with improved bioavailability.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Taille de particule
/
Solubilité
/
Vecteurs de médicaments
/
Pharmacocinétique
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Biodisponibilité
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Chimie
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Administration par voie orale
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Rat Sprague-Dawley
/
Silice
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Matériaux revêtus, biocompatibles
Limites du sujet:
Animals
langue:
Zh
Texte intégral:
Acta Pharmaceutica Sinica
Année:
2012
Type:
Article