Synthesis and antitumor activity of novel 2-(1-substituted-piperidin-4-ylamino)quinazolines as antitumor agents / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1164-1178, 2012.
Article
Dans Anglais
| WPRIM
| ID: wpr-274682
ABSTRACT
A variety of novel 2-(1-substituted-piperidine-4-ylamino)quinazoline derivatives were prepared and their antiproliferative activities on five cancer cell lines were evaluated by MTT assay. Quinazolines 4j-4l, 5a, 5b and 5d bearing a small hydrophobic alkyl group on piperidine ring exhibited potent antitumor activities with IC50 values at micromolar level. Compound 41 displayed significant in vivo antitumor activity with 72.9% inhibition on H22 tumor growth and 80% inhibition on Lewis lung cancer growth at a dose of 200 mg x kg(-1).
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Pharmacologie
/
Quinazolines
/
Tests de criblage d'agents antitumoraux
/
Chimie
/
Carcinome pulmonaire de Lewis
/
Concentration inhibitrice 50
/
Lignée cellulaire tumorale
/
Tumeurs du foie
/
Souris de lignée C57BL
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Acta Pharmaceutica Sinica
Année:
2012
Type:
Article
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