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Research progress of the atypical kinetic profiles of cytochrome P450 enzymes / 药学学报
Acta Pharmaceutica Sinica ; (12): 725-729, 2012.
Article Dans Chinois | WPRIM | ID: wpr-276253
ABSTRACT
Cytochrome P450 enzymes are composed of many isozymes and involved in the biotransformation of both exogenous and endogenous substances. A growing number of studies have found that the P450 enzymes do not always follow the classical Michaelis-Menten kinetics, but show atypical kinetic behavior, which is also the current research hotspot. In this paper, the category and mechanisms of atypical kinetics of the P450 enzyme were reviewed, providing theoretical basis for the research of enzyme kinetics.
Sujets)
Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Pharmacologie / Liaison aux protéines / Spécificité du substrat / Naphtoflavones / Sites de fixation / Cinétique / Chimie / Cytochrome P-450 enzyme system / Activation enzymatique / Cytochrome P-450 CYP3A Limites du sujet: Animaux / Humains langue: Chinois Texte intégral: Acta Pharmaceutica Sinica Année: 2012 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Pharmacologie / Liaison aux protéines / Spécificité du substrat / Naphtoflavones / Sites de fixation / Cinétique / Chimie / Cytochrome P-450 enzyme system / Activation enzymatique / Cytochrome P-450 CYP3A Limites du sujet: Animaux / Humains langue: Chinois Texte intégral: Acta Pharmaceutica Sinica Année: 2012 Type: Article