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Neuroprotective effect of longistyline A against corticosterone-induced neurotoxicity in PC12 cells / 药学学报
Acta Pharmaceutica Sinica ; (12): 600-603, 2012.
Article Dans Chinois | WPRIM | ID: wpr-276274
ABSTRACT
This study is to investigate the protective effect of longistyline A against corticosterone-induced neurotoxicity in PC12 cells. While PC12 cells were exposed to 100 micromol x L(-1) corticosterone for 48 h, cell survival rate was reduced and lactate dehydrogenase (LDH) release increased. In parallel, corticosterone caused significant elevations of DNA fragmentation, [Ca2+]i and caspase-3 activity. However, when the PC12 cells were incubated with longistyline A (4.0, 8.0 and 16.0 micromol x L(-1)) in the presence of 100 micromol x L(-1) corticosterone for 48 h, the effects were evidently alleviated, but dose-dependent manner was not obvious. In summary, longistyline A could generate a neuroprotective effect against corticosterone-induced neurotoxicity in PC12 cells possibly by decreasing [Ca2+]i and caspase-3 activity.
Sujets)
Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Pharmacologie / Phénols / Plantes médicinales / Corticostérone / Structure moléculaire / Survie cellulaire / Chimie / Calcium / Cellules PC12 / Feuilles de plante Limites du sujet: Animaux langue: Chinois Texte intégral: Acta Pharmaceutica Sinica Année: 2012 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Pharmacologie / Phénols / Plantes médicinales / Corticostérone / Structure moléculaire / Survie cellulaire / Chimie / Calcium / Cellules PC12 / Feuilles de plante Limites du sujet: Animaux langue: Chinois Texte intégral: Acta Pharmaceutica Sinica Année: 2012 Type: Article