Combinatorial RNAi and its application in cancer gene therapy / 药学学报
Acta Pharmaceutica Sinica
;
(12): 573-579, 2012.
Article
Dans Chinois
| WPRIM
| ID: wpr-276278
ABSTRACT
RNA interference (RNAi) has been proved as a novel approach for gene therapy. However, RNAi mono-therapy only aims at single gene, it therefore may ultimately fail to cure cancers caused by polygene variation. To overcome the deficiency of RNAi mono-therapy, "combinatorial RNA interference" (coRNAi) was put forward as a new strategy. By co-expressing the inducers of RNAi triggering single or multiple targets directly and other RNA- or protein-based silencers, coRNAi keeps target genes silent, prevents carcinogenic progression and induces apoptosis of tumor cells. This paper mainly reviews the major strategies of coRNAi and their applications in cancer gene therapy.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Oncogènes
/
Anatomopathologie
/
Thérapeutique
/
Thérapie génétique
/
Petit ARN nucléaire
/
Apoptose
/
MicroARN
/
Petit ARN interférent
/
Interférence par ARN
/
Génétique
Limites du sujet:
Animaux
/
Humains
langue:
Chinois
Texte intégral:
Acta Pharmaceutica Sinica
Année:
2012
Type:
Article
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