Use of autologous tumor vaccine in preventing recurrence of hepatocellular carcinoma / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 772-775, 2005.
Article
Dans Chinois
| WPRIM
| ID: wpr-276358
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the effects of autologous tumor vaccines in preventing recurrences of hepatocellular carcinoma (HCC).</p><p><b>METHODS</b>From March 1999 to June 2003, 80 patients with HCC undergoing resections were randomly assigned into a tumor vaccine group (n=40) and a control group (n=40). Tumor vaccines, consisting of formalin-fixed HCC tissue fragments, biodegradable sustained-releasers of granulocyte-macrophage-colony stimulating factor, interleukin-2, and an adjuvant, were developed. Every vaccine group patient received 3 vaccinations at a 2-week interval and the control group just received the adjuvant. Delayed-type-hypersensitivity (DTH) test and recurrent rates were analyzed.</p><p><b>RESULTS</b>Eight patients of the vaccine group and five patients of the control group were lost in the follow-up. Thirty-two patients completed the tumor vaccine procedure and no essential adverse effects occurred. 23/32 patients developed DTH responses against the fragments of HCC. The follow-up averaged 34.3 months (from 15 to 55 months). 1-, 2-, 3-year recurrence rates of the vaccine group were 12.6%, 35.9% and 54.0%, respectively; 1-, 2-, 3-year recurrence rates of the control group were 31.6%, 61.3% and 72.1%, respectively. The recurrent rate was significantly better in the tumor vaccine group than in the control group (P = 0.037).</p><p><b>CONCLUSIONS</b>Autologous tumor vaccine is a promising adjunctive modality to prevent recurrence of human HCC.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Période postopératoire
/
Chirurgie générale
/
Thérapeutique
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Facteur de stimulation des colonies de granulocytes et de macrophages
/
Interleukine-2
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Vaccination
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Carcinome hépatocellulaire
/
Vaccins anticancéreux
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Utilisations thérapeutiques
/
Tumeurs du foie
Limites du sujet:
Adulte
/
Adulte très âgé
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Chinese Journal of Hepatology
Année:
2005
Type:
Article
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