Protective effects of polysacchride of Spirulina platensis and Sargassum thunbeergii on vascular of alloxan induced diabetic rats / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 211-215, 2005.
Article
Dans Chinois
| WPRIM
| ID: wpr-276610
ABSTRACT
<p><b>OBJECTIVE</b>To study the protective effects of polysaccharide of Spirulina platensis and Sargassum thunbeergii on vascular of alloxan (ALX) induced diabetic rats.</p><p><b>METHOD</b>With the doses of polysaccharide of Spirulina platensis (PSP) and Sargassum thunbeergii (PST) compound (11) 12.261, 36.783, 110.349 mg x kg(-1) by i.g. administration to alloxan induced diabetic rats respectively for 6 weeks. Then the blood glucose and the TC, HDL-C, TG, NO, ET in serum were detected. The contraction and relaxation response to NE and ACh in aortic rings of the alloxan induced diabetic rats has been studied.</p><p><b>RESULT</b>The results showed the compound of PSP and PST could decrease the blood glucose and the TC, TG, NO, ET in serum and increase HDL-C than in the alloxan induced diabetic rats. The contraction responses to NE in aortic rings of the alloxan induced diabetic rats were significantly elevated in the normal rats, and the responses to ACh were significantly lower. PSP and PST compound could significantly lower the responses to NE and significantly elevate the responses to ACh in aortic rings of the alloxan induced diabetic rats.</p><p><b>CONCLUSION</b>PSP and PST compound could decrease blood glucose and could protect the vascular of alloxan induced diabetic rats.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Aorte thoracique
/
Pharmacologie
/
Polyosides
/
Polyosides bactériens
/
Triglycéride
/
Sang
/
Glycémie
/
Chimie
/
Cholestérol
/
Endothélines
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
China Journal of Chinese Materia Medica
Année:
2005
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS