Studies on the renal toxicity caused by aristolochic acids (AAs) and Chinese herbs containing AAs / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 10-14, 2004.
Article
Dans Chinois
| WPRIM
| ID: wpr-276679
ABSTRACT
The article summarized the general situation of the study on the renal toxicity caused by aristolochic acids (AAs) and Chinese herbs containing AAs. The renal lesion induced by AAs and Chinese herbs containing AAs locates mainly in renal tubules, and glomeruluses have no obvious histological change. The short term administration of large doses causes acute renal epithelia denaturalization and tubular necrosis, but the long-term administration may result in chronically progressive interstitial fibrosis of the kidney. Renal failure may occur following both acute and chronic renal lesion. The renal function should be strictly monitored while one is using the Chinese herbs containing AAs, and the dosage and duration for the treatment must be limited to prevent renal toxicity.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Plantes médicinales
/
Fibrose
/
Médicaments issus de plantes chinoises
/
Chimie
/
Aristolochiaceae
/
Acides aristolochiques
/
Insuffisance rénale
/
Toxicité
/
Rein
Limites du sujet:
Animaux
/
Humains
langue:
Chinois
Texte intégral:
China Journal of Chinese Materia Medica
Année:
2004
Type:
Article
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