Synthesis and preliminary studies of O-(2-18F fluoroethyl)-L-tyrosine as a positron emission tomography imaging agent / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 370-372, 2002.
Article
Dans Chinois
| WPRIM
| ID: wpr-278162
ABSTRACT
<p><b>OBJECTIVE</b>To develop a 18F-labeled amino acid, O-(2-[18F]fluoroethyl) - L-tyrosine(18F-FET), as a positron emission tomography (PET) tracer for imaging cerebral tumors.</p><p><b>METHODS</b>18F-FET was synthesized. Preclinical studies including sterility, endotoxin, and toxicity tests were performed. Two brain tumor cases were studied using 18F-FET and compared with 18F-FDG.</p><p><b>RESULTS</b>Radiochemical purity of 18F-FET was over 95% which remained stable for 6 hours. The 18F-FET injection was sterile and its endotoxin content accorded with the standards of Chinese Pharmacopoeia. The uptake of 18F-FET in the normal brain tissues was significantly lower than that of the tumor, and the images of the brain tumor were clearer than those of 18F-FDG.</p><p><b>CONCLUSION</b>18F-FET can accumulate in the tumor tissues to give high quality images. It suggests that 18F-FET may be a safe and effective tracer for brain tumor imaging.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Sarcome 180 de Crocker
/
Tyrosine
/
Tumeurs du cerveau
/
Imagerie diagnostique
/
Radio-isotopes du fluor
/
Tomoscintigraphie
/
Glioblastome
/
Fluorodésoxyglucose F18
Type d'étude:
Etude diagnostique
Limites du sujet:
Animaux
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Acta Academiae Medicinae Sinicae
Année:
2002
Type:
Article
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