Role of PKCbeta in the malignant tumors and enzastaurin, a PKCbeta inhibitor / 药学学报
Acta Pharmaceutica Sinica
; (12): 449-455, 2009.
Article
de Zh
| WPRIM
| ID: wpr-278240
Bibliothèque responsable:
WPRO
ABSTRACT
Protein kinase C beta (PKCbeta) is a multifunctional serine/threonine protein kinase, which plays an important role in many cell signaling pathways. PKCbeta takes part in multiple physiological processes, including regulation of the cell cycle, differentiation, proliferation, apoptosis and angiogenesis. Increased PKCbeta activity has been observed in many human cancers, such as colon, breast and haematological malignancies. At present, Enzastaurin is mostly studied in preclinical and clinical studies, which is a selective PKCbeta inhibitor. This review focuses on the functional properties of PKCbeta, its role played in tumors and Enzastaurin.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Anatomopathologie
/
Pharmacologie
/
Protéine kinase C
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Chimie
/
Essais cliniques comme sujet
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Lignée cellulaire tumorale
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Utilisations thérapeutiques
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Inhibiteurs de protéines kinases
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Prolifération cellulaire
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Traitement médicamenteux
Limites du sujet:
Animals
/
Humans
langue:
Zh
Texte intégral:
Acta Pharmaceutica Sinica
Année:
2009
Type:
Article