Comparative pharmacophore analysis of dual dopamine D2/5-HT(2A) receptor antagonists / 药学学报
Acta Pharmaceutica Sinica
;
(12): 314-320, 2009.
Article
Dans Chinois
| WPRIM
| ID: wpr-278264
ABSTRACT
Dual dopamine D2/5-HT2A receptor antagonists have potent activity and are referred to atypical antipsychotics due to their lower propensity to elicit EPS and their moderate efficacy toward negative symptoms. However, an on-going challenge in developing atypical antipsychotics drugs is to maintain the favorable profiles and avoid of cardiovascular risk. In this paper, comparative pharmacophore analysis of dual dopamine D2/5-HT2A receptor antagonists, hERG K+ channel blockers, and alA adrenoceptor antagonists is carried out, and the results could give some insight into multi-target drug design.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Relation structure-activité
/
Conception de médicament
/
Structure moléculaire
/
Chimie
/
Systèmes de délivrance de médicaments
/
Récepteur D2 de la dopamine
/
Récepteurs alpha-1 adrénergiques
/
Récepteur de la sérotonine de type 5-HT2A
/
Canaux potassiques éther-à-go-go
/
Antagonistes des récepteurs alpha-1 adrénergiques
langue:
Chinois
Texte intégral:
Acta Pharmaceutica Sinica
Année:
2009
Type:
Article
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