Reactive oxygen species and fibrosis in tissues and organs - review / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 1284-1288, 2012.
Article
de Zh
| WPRIM
| ID: wpr-278389
Bibliothèque responsable:
WPRO
ABSTRACT
Reactive oxygen species (ROS) is a kind of molecules derived by oxygen in the metabolic process of aerobic cells, which mainly includes superoxide, hydroxyl radicals, alkoxyl, hydrogen peroxide, hypochlorous acid, ozone, etc. They can destroy the structure and function of cells through the damage of biological macromolecules such as DNA, proteins and the lipid peroxidation. ROS also can regulate the proliferation, differentiation and apoptosis of cells through several signaling pathways and participate in fibrogenesis of many organs including hepatic and pulmonary fibrosis. Recent study shows that ROS might have an important effect on the forming of myelofibrosis. Consequently, ROS plays a significant role in the fibrogenesis of tissues and organs. In this review, the relevance between ROS and common tissues and organs fibrosis is summarized.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Anatomopathologie
/
Fibrose pulmonaire
/
Moelle osseuse
/
Maladies de la moelle osseuse
/
Fibrose
/
Espèces réactives de l'oxygène
/
Foie
/
Cirrhose du foie
/
Poumon
/
Métabolisme
Limites du sujet:
Animals
/
Humans
langue:
Zh
Texte intégral:
Journal of Experimental Hematology
Année:
2012
Type:
Article