Effects of COX-2 inhibitor celecoxib on expressions of VEGF, b-FGF and TGF-β mRNA in acute leukemia cells / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 1086-1089, 2012.
Article
de Zh
| WPRIM
| ID: wpr-278430
Bibliothèque responsable:
WPRO
ABSTRACT
This study was aimed to investigate the influence and significance of celecoxib (specific inhibitor of cyclooxygenase-2) on mRNA expressions of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (b-FGF), transforming growth factor β (TGF-β) in acute leukemia cells. The expressions of VEGF, b-FGF, TGF-β mRNA were measured by RT-PCR in acute leukemia cells treated with celecoxib (80 µmol/L, for 48 h) or with PBS. The results showed that the obvious expressions of VEGF, b-FGF, TGF-β mRNA were observed in acute leukemia cells. By using Pearson correlation analysis, there was positive correlation between VEGF mRNA and b-FGF mRNA expressions (r = 0.559, P = 0.001), and negative correlation between VEGF and TGF-β mRNA expressions (r = -0.4, P = 0.029). Expression levels of VEGF, b-FGF, TGF-β mRNA in experimental group were lower than that in control group (P < 0.01). It is concluded that COX-2 inhibitor celecoxib can inhabit vascular endothelial growth through down-regulating the mRNA expression of VEGF, b-FGF and TGF-β in acute leukemia cells. COX-2 inhibitor may offer supplemental effect for treating acute leukemia.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Pharmacologie
/
Pyrazoles
/
Sulfonamides
/
ARN messager
/
Transduction du signal
/
Leucémies
/
Facteur de croissance fibroblastique de type 2
/
Facteur de croissance transformant bêta
/
Facteur de croissance endothéliale vasculaire de type A
/
Traitement médicamenteux
Limites du sujet:
Adult
/
Female
/
Humans
/
Male
langue:
Zh
Texte intégral:
Journal of Experimental Hematology
Année:
2012
Type:
Article