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Risk factors for coronary artery lesions secondary to Kawasaki disease in children / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics ; (12): 927-931, 2015.
Article Dans Chinois | WPRIM | ID: wpr-279023
ABSTRACT
<p><b>OBJECTIVE</b>To explore the risk factors for coronary artery lesions (CAL) secondary to Kawasaki disease (KD) in children.</p><p><b>METHODS</b>The medical data of 895 children with KD were retrospectively reviewed. The patients were classified into two groups according to the presence of CAL CAL (n=284) and control (n=611). The clinical and laboratory indices were compared between the two groups. The risk factors for the development of CAL in children with KD were identified by multiple logistic regression analysis.</p><p><b>RESULTS</b>Male gender (OR=1.712), occurrence of non-CAL complications (OR=2.028), atypical KD (OR=3.655), intravenous immunoglobulin (IVIG) resistance (OR=2.912), more than 5 days of fever duration before IVIG treatment (OR=1.350), and increased serum procalcitonin (PCT) level (OR=1.068) were the independent risk factors for the development of CAL in children with KD (P<0.05), whereas increased serum albumin (Alb) level was a protective factor (OR=0.931, P<0.05). The areas under the receiver operating characteristic curve of serum PCT and ALB for prediction of the development of CAL in children with KD were 0.631 and 0.558, respectively.</p><p><b>CONCLUSIONS</b>Male gender, atypical KD, occurrence of other non-CAL complications, long duration of fever and IVIG resistance are associated with an increased risk for CAL in children with KD. Serum PCT and ALB have little value in the prediction of CAL in children with KD.</p>
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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Précurseurs de protéines / Sang / Maladie des artères coronaires / Calcitonine / Peptide relié au gène de la calcitonine / Facteurs de risque / Immunoglobulines par voie veineuse / Utilisations thérapeutiques / Maladie de Kawasaki Type d'étude: Etude d'étiologie / Étude pronostique / Facteurs de risque Limites du sujet: Adolescent / Enfant / Enfant d'âge préscolaire / Femelle / Humains / Bébé / Mâle langue: Chinois Texte intégral: Chinese Journal of Contemporary Pediatrics Année: 2015 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Précurseurs de protéines / Sang / Maladie des artères coronaires / Calcitonine / Peptide relié au gène de la calcitonine / Facteurs de risque / Immunoglobulines par voie veineuse / Utilisations thérapeutiques / Maladie de Kawasaki Type d'étude: Etude d'étiologie / Étude pronostique / Facteurs de risque Limites du sujet: Adolescent / Enfant / Enfant d'âge préscolaire / Femelle / Humains / Bébé / Mâle langue: Chinois Texte intégral: Chinese Journal of Contemporary Pediatrics Année: 2015 Type: Article